PHOSPHATE, AMMONIUM, MAGNESIUM AND IRON NUTRITION OF STREPTOMYCES-HYGROSCOPICUS WITH RESPECT TO RAPAMYCIN BIOSYNTHESIS

被引：29

作者：

CHENG, YR ^{[1
]}

HAUCK, L ^{[1
]}

DEMAIN, AL ^{[1
]}

机构：

[1] MIT,FERMENTAT MICROBIOL LAB,CAMBRIDGE,MA 02139

来源：

JOURNAL OF INDUSTRIAL MICROBIOLOGY | 1995年 / 14卷 / 05期

关键词：

PHOSPHATE; AMMONIUM; MAGNESIUM; IRON; NUTRITION; RAPAMYCIN BIOSYNTHESIS; STREPTOMYCES HYGROSCOPICUS;

D O I：

10.1007/BF01569962

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Phosphate, ammonium and magnesium salts interfered with rapamycin production by Streptomyces hygroscopicus at concentrations optimal for growth. These observations point to the existence of phosphorus, magnesium and nitrogen-negative regulation mechanisms for rapamycin biosynthesis. On the other hand, Fe2+ stimulated rapamycin production at concentrations greater than that required for growth.

引用

页码：424 / 427

页数：4

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