DOES INTERMITTENT SUN EXPOSURE CAUSE BASAL-CELL CARCINOMA - A CASE-CONTROL STUDY IN WESTERN-AUSTRALIA

被引:338
作者
KRICKER, A
ARMSTRONG, BK
ENGLISH, DR
HEENAN, PJ
机构
[1] INT AGCY RES CANC,F-69372 LYON 08,FRANCE
[2] UNIV WESTERN AUSTRALIA,DEPT PUBL HLTH,NEDLANDS,WA 6009,AUSTRALIA
[3] UNIV WESTERN AUSTRALIA,DEPT PATHOL,NEDLANDS,WA 6009,AUSTRALIA
[4] AUSTRALIAN INST HLTH & WELF,CANBERRA,ACT 2601,AUSTRALIA
关键词
D O I
10.1002/ijc.2910600411
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Our report deals with the relationship of pattern and timing of sun exposure to basal cell carcinoma (BCC) in a population-based case-control study conducted in Western Australia in 1988. The main measure of intermittent exposure was based on the amount of exposure on non-working days relative to that over the whole week. Outdoor recreational activities, holidays and sunburn were also considered to be markers of intermittent exposure. We observed a statistically significant increase in risk of BCC with increasing proportion of weekly sun exposure obtained at the weekend, especially in late teenage (OR 3.9, 95% CI 1.9-7.8 for maximum intermittency of exposure), exposure of the site of skin cancer during holidays (OR = 1.9, 95% CI 1.1-3.1 for the highest exposure quarter) and sunburn to the site (ORs of 1.8 for 3-10 and 1.5 for 11 + sunburns in a lifetime). Risk of BCC increased substantially with increasing intermittency in poor tanners but not at all in good tanners. Our data suggest that a particular amount of sun exposure delivered in infrequent, probably intense increments will increase risk of BCC more than a similar dose delivered more continuously over the same total period of time. (C) 1995 Wiley-Liss, Inc.
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页码:489 / 494
页数:6
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