GASTRIC-ACID INHIBITORY-ACTION OF A GABA-RELATED COMPOUND, 3-AMINO-3-PHENYLPROPIONIC ACID, IN THE RAT

被引:12
作者
HARA, N
NATSUME, Y
HARA, Y
GOTO, Y
机构
[1] TOKUSHIMA BUNRI UNIV,DEPT PHARMACOL,YAMASHIRO CHO,TOKUSHIMA 770,JAPAN
[2] SUMITOMO PHARMACEUT CO LTD,RES LABS,OSAKA 554,JAPAN
关键词
(Central mechanism); GABA mimetic; Gastric secretion; Vagal stimulation;
D O I
10.1016/0014-2999(90)90397-O
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The acid inhibitory properties of 3-amino-3-phenylpropionic acid, a structural GABA analogue, were studied in the perfused rat stomach preparation. 3-Amino-3-phenylpropionic acid, 10 and 30 mg/kg i.v., dose dependently supressed the gastric acid secretion induced by baclofen (2 mg/kg s.c.). This secretagogue action had been shown to be unaffected by either GABAA or GABAB receptor antagonists. The i.v. administration of 3-amino-3-phenylpropionic acid (3 and 10 mg/kg) was also effective to abolish the acid stimulatory effects of muscimol (1 mg/kg i.v.) and 2-deoxy-D-glucose (200 mg/kg i.v.). 3-Amino-3-phenylpropionic acid, even at the high dose (30 mg/kg i.v.) had no influence on the acid output in response to histamine and bethanechol. Furthermore, 3-amino-3-phenylpropionic acid had no significant effect on the acid secretion induced by electrical vagal stimulation. These results indicate that the antisecretory effect of 3-amino-phenylpropionic acid is different from those of antimuscarinics, H2-receptor antagonists and vagal blockade. Together, the results suggest that 3-amino-3-phenylpropionic acid might act in the brain to inhibit central regulation mechanisms of gastric acid secretion, probably through GABA mechanisms. © 1990.
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页码:17 / 23
页数:7
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