PROPAGATION OF SINDBIS VIRUS MURRAY VALLEY ENCEPHALITIS VIRUS AND GETAH VIRUS

A study was made of the propagation of 3 arboviruses, namely, Sindbis (MRM39), Murray Valley encephalitis (MRM66) and Getah (N544), in 12-day-old embryonated chicken eggs following inoculation into the allantoic cavity and in chickens hatching from infected eggs. Sindbis virus was detected from 1 to 5 days after inoculation. Its highest titre occurred in the allantoic fluid 42 hours after inoculation. Murray Valley encephalitis virus, which appeared 24 hours after inoculation and persisted for 6 days, occurred in highest titre in the brain 3 days after inoculation. Getah virus did not propagate in chicken embryos inoculated by this route and viruses could not be isolated from any chicken hatched from infected eggs. © 1968.