EFFECTS OF AMORPHOUS SILICON DIOXIDES ON DRUG DISSOLUTION

被引：46

作者：

YANG, KY ^{[1
]}

GLEMZA, R ^{[1
]}

JAROWSKI, CI ^{[1
]}

机构：

[1] ST JOHNS UNIV,COLL PHARM & ALLIED HLTH PROFESS,DEPT ALLIED HLTH & IND SCI,JAMAICA,NY 11439

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 05期

关键词：

Dispersions; solid—effect of amorphous silicon dioxides on prednisone; digoxin; griseofulvin; simulated GI fluids; solvent deposition compared to ball milling; Dissolution rate—effects of amorphous silicon dioxides on prednisone; Silicon dioxide; amorphous—effect on dissolution rates of prednisone; griseofulvin in simulated GI fluids;

D O I：

10.1002/jps.2600680511

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The dissolution profiles of prednisone, digoxin, and griseofulvin in simulated GI fluids were determined after solvent deposition or ball milling with three commercially available grades of amorphous silicon dioxide. The former procedure resulted in adsorbates showing evidence of drug entrapment by the two grades with larger average pore diameters. Ball milling the drugs with the grade possessing the largest average particle diameter produced triturations with the slowest dissolution rates. A relationship between drug dissolution and extent of dilution with the amorphous silicon dioxides was shown. Particle‐size measurements revealed that the ball milling procedure was more apt to broaden the size distribution as compared with the solvent‐deposition method of drug incorporation. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：560 / 565

页数：6

共 5 条

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[5]

1975, US PHARMACOPEIA, P765

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