MECHANISM FOR DENTAL-CARIES BASED ON CHEMICAL PROCESSES AND DIFFUSION PHENOMENA DURING INVITRO CARIES SIMULATION ON HUMAN TOOTH ENAMEL

被引:107
作者
FEATHERSTONE, JDB [1 ]
DUNCAN, JF [1 ]
CUTRESS, TW [1 ]
机构
[1] VICTORIA UNIV WELLINGTON,DEPT CHEM,WELLINGTON,NEW ZEALAND
基金
英国医学研究理事会;
关键词
D O I
10.1016/0003-9969(79)90057-8
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Artificial carious lesions were produced in a range of lactate buffers containing disodium-methane-hydroxy-diphosphonate and the depths of the lesions were measured. The depth of the body of the lesion depended on the calculated concentration of un-ionized lactic acid (HL), and the innermost boundary depended on HL concn. and pH. Apparent diffusion coefficients of the order 10-10cm2/s were calculated from the boundary movement. A mechanism is proposed for the caries process. Diffusion, predominantly of the un-ionized chemical species HL, H3PO4, CaHPO4, Ca(H2PO4)2 and CaL2 occurs through the intercrystalline and interprismatic pores of enamel filled with water and protein. Dissolution takes place throughout the lesion by H+ and L- as HL dissociates. The outer enamel surface is partly protected by reversible adsorption of suitable chemical species. © 1979.
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页码:101 / 112
页数:12
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