ALPHA-1-ANTICHYMOTRYPSIN SUPPORTS SHORT-TERM SURVIVAL OF CEREBRAL NEURONS IN CULTURE

被引：10

作者：

MIZUGUCHI, M

KIM, SU

机构：

[1] Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC

来源：

NEUROSCIENCE LETTERS | 1991年 / 124卷 / 02期

关键词：

ALPHA-1-ANTICHYMOTRYPSIN; ALZHEIMERS DISEASE; AMYLOID; NEURON; TISSUE CULTURE; PROTEASE INHIBITOR;

D O I：

10.1016/0304-3940(91)90085-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

alpha-1-Antichymotrypsin (ACT) is a component of the amyloid deposits in Alzheimer's disease. To elucidate its biological activities in the central nervous system, dissociated cultures of rat cerebral neurons were grown in a serum-free medium containing ACT. The addition of ACT (0.1-1-mu-g/ml) enhanced survival of microtubule-associated protein 2-immunoreactive neurons under the culture conditions examined.

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页码：166 / 168

页数：3

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