POSSIBLE CATALYTIC ACTIVITY OF DNA IN THE REACTION BETWEEN THE ANTITUMOR DRUG CIS-DIAMMINEDICHLOROPLATINUM(II) AND THE INTERCALATOR N-METHYL-2,7-DIAZAPYRENIUM

被引：20

作者：

GAUCHERON, F ^{[1
]}

MALINGE, JM ^{[1
]}

BLACKER, AJ ^{[1
]}

LEHN, JM ^{[1
]}

LENG, M ^{[1
]}

机构：

[1] UNIV STRASBOURG 1,INST LE BEL,F-67070 STRASBOURG,FRANCE

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 09期

关键词：

CISPLATIN; PLATINUM-TRIAMINE; DIETHYL PYROCARBONATE;

D O I：

10.1073/pnas.88.9.3516

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The platinum(II) complex cis-[Pt(NH3)2(N7-N-methyl-2-diazapyrenium)Cl]2+ formed in the reaction between cis-diamminedichloroplatinum(II) and N-methyl-2,7-diazapyrenium reacts with N7 of guanine residues in DNA. The resulting adduct is kinetically inert within single-stranded DNA. Within double-stranded DNA, it is kinetically inert in 1 M NaClO4 and becomes labile as the salt concentration is decreased. Two products, cis-[Pt(NH3)2(N7-N-methyl-2-diazapyrenium)H2O]3+ and N-methyl-2,7-diazapyrenium, are released. The conformation of the platinated DNA is different in low- and high-salt conditions as shown by the chemical probe diethyl pyrocarbonate. These results are discussed in relation with a possible catalytic role played by the double-stranded DNA.

引用

页码：3516 / 3519

页数：4

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