PRIMING EFFECTS OF MAMMALIAN TACHYKININS ON HUMAN NEUTROPHILS

被引：25

作者：

BRUNELLESCHI, S ^{[1
]}

TARLI, S ^{[1
]}

GIOTTI, A ^{[1
]}

FANTOZZI, R ^{[1
]}

机构：

[1] UNIV FERRARA,INST PHARMACOL,I-44100 FERRARA,ITALY

来源：

LIFE SCIENCES | 1991年 / 48卷 / 02期

关键词：

D O I：

10.1016/0024-3205(91)90416-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The undecapeptide substance P (SP) is known to activate different cell types involved in inflammatory and immune processes. By evaluating primed stimulation of human neutrophils, we now demonstrate that SP (10 nM - 0.1 mM) dose-dependently enhances superoxide anion production from cells stimulated by the phospholipid mediator Platelet Activating Factor (PAF). We also provide evidence that neurokinin A (NKA), which is released, as well as SP, from C fibers of sensory nerves, potentiates PAF-evoked superoxide anion generation, while neurokinin B (NKB) is ineffective. © 1991.

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页码：PL1 / PL5

页数：5

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