SEX-HORMONE BINDING GLOBULIN LEVELS IN ADOLESCENT SUBJECTS WITH DIABETES-MELLITUS

被引：12

作者：

HOLLY, JMP

DUNGER, DB

ALOTHMAN, SA

SAVAGE, MO

WASS, JAH

机构：

[1] Departments of Chemical Endocrinology, Child Health, and Reproductive Physiology, St Bartholomew's Hospital, London

[2] Department of Paediatrics, The John Radcliffe Hospital, Oxford

来源：

DIABETIC MEDICINE | 1992年 / 9卷 / 04期

关键词：

DIABETES-MELLITUS; PUBERTY; SEX HORMONE BINDING GLOBULIN;

D O I：

10.1111/j.1464-5491.1992.tb01799.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In normal adolescents there is a pubertal fall in circulating levels of sex hormone binding globulin (SHBG) in both sexes which is not explained by classically accepted mechanisms of control of SHBG. Recent in vitro and in vivo evidence has suggested that SHBG is inversely regulated by insulin. In view of this we have compared SHBG levels in 80 adolescent subjects with Type 1 diabetes to those in 61 normal adolescents. In both normals and in Type 1 diabetic subjects there was a pubertal fall in SHBG levels. Contrary to expectations, SHBG levels were not elevated in those with diabetes, but prepubertally were significantly lower in both sexes (boys mean +/- SD, 70 +/- 28 nmol l-1, normals 130 +/- 52 nmol l-1, p < 0.001; girls, 61 +/- 17 nmol l-1, normals 110 +/- 23 nmol l-1, p = 0.01). In pubertal subjects no differences in SHBG levels were seen between the two groups, or between either sex within any group. In subjects with Type 1 diabetes SHBG levels were unrelated to metabolic control as reflected by HbA, but were inversely related to pubertal stage (r = 0.55, p < 0.001). In prepubertal subjects with diabetes, in whom abnormal SHBG levels were found, these levels were weakly related to insulin dose (r = 0.33, p < 0.05); no such relationship was found in the other groups. The significance of the abnormal SHBG levels in prepubertal children with diabetes and its relationship to any irregularities of their sexual development is unclear.

引用

页码：371 / 374

页数：4

共 17 条

[1]

Tattersall RB, Pyke DA., Growth in diabetic children: Studies in identical twins, Lancet, 2, pp. 1105-1109, (1973)

[2]

Jivani SKM, Rayner PHW., Does control influence the growth of diabetic children?, Arch Dis Child, 48, pp. 109-115, (1973)

[3]

Poretsky L., Kahn MF., The gonadotrophic function of insulin, Endocrine Rev, 8, pp. 132-141, (1987)

[4]

Rosner W., The functions of corticosteroid‐binding globulin and sex hormone‐binding globulin: recent advances, Endocrine Rev, 11, pp. 80-91, (1990)

[5]

Ando S., Rubens R., Rottiers R., Androgen plasma levels in male diabetics, J Endocrinol Invest, 7, pp. 21-24, (1984)

[6]

Nyholm H., Djursing H., Hagen C., Agner T., Bennett P., Svenstrup B., Androgens and estrogens in postmenopausal insulin‐treated diabetic women, J Clin Endocrinol Metab, 69, pp. 946-949, (1989)

[7]

Holly JMP, Smith CP, Dunger DB, Howell R., Chard T., Savage MO, Et al., Relationship between the pubertal fall in sex hormone‐binding globulin and insulin‐like growth factor binding protein‐1. A synchronised approach to pubertal development?, Clin Endocrinol, 31, pp. 277-284, (1989)

[8]

Tanner JM, Whitehouse RH., Clinical longitudinal standards for height, weight, height velocity, weight velocity and stages of puberty, Arch Dis Child, 51, pp. 170-179, (1976)

[9]

Kay JDS, Standing S., Strang S., Dunger DB., Glycated haemoglobin in specimens collected by finger prick from children: performance data, comparison with venous blood specimens and reference values, Ann Clin Biochem, 25, pp. 595-596, (1988)

[10]

Wathen NC, Perry LA, Rubenstein E., Chard T., A relationship between sex hormone binding globulin and dehydroepiandrosterone sulfate in normally menstruating females, Gynecol Endocrinol, 1, pp. 47-50, (1987)

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