DETERMINATION OF CAFFEINE AND POTASSIUM SORBATE IN A NEONATAL ORAL SOLUTION BY HPLC

被引：4

作者：

BARNES, AR ^{[1
]}

机构：

[1] UNIV ASTON,INST PHARMACEUT SCI,BIRMINGHAM B4 7ET,W MIDLANDS,ENGLAND

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 80卷 / 2-3期

关键词：

CAFFEINE; POTASSIUM SORBATE; HPLC; ORAL SOLUTION;

D O I：

10.1016/0378-5173(92)90285-A

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A reversed-phase HPLC method was developed and validated for the determination of caffeine and potassium sorbate in a neonatal oral solution. Chromatography was performed with a 100 x 4.5 mm Spherisorb 5-mu-m hexyl column with a mobile phase of 12% acetonitrile in 0.1 M sodium acetate buffer pH 4.5 and ultraviolet detection at 258 nm. The method is stability indicating and there was no interference from a number of common formulation ingredients, although benzoic acid did interfere.

引用

页码：267 / 270

页数：4

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