INVIVO TREATMENT WITH A MONOCLONAL-ANTIBODY TO INTERFERON-GAMMA NEITHER AFFECTS THE SURVIVAL NOR THE INCIDENCE OF LUPUS-NEPHRITIS IN THE MRL/LPR-LPR MOUSE

被引：25

作者：

NICOLETTI, F

MERONI, P

DIMARCO, R

BARCELLINI, W

BORGHI, MO

GARIGLIO, M

MATTINA, A

GRASSO, S

LANDOLFO, S

机构：

[1] UNIV MILAN,INST INTERNAL MED INFECT DIS & IMMUNOPATHOL,I-20122 MILAN,ITALY

[2] UNIV TURIN,DEPT MED PATHOL & METAB DIS 2,I-10124 TURIN,ITALY

[3] UNIV CATANIA,DEPT PATHOL,I-95124 CATANIA,ITALY

[4] UNIV TURIN,INST MICROBIOL & VIROL,I-10124 TURIN,ITALY

来源：

IMMUNOPHARMACOLOGY | 1992年 / 24卷 / 01期

关键词：

IFN-GAMMA; ANTI-GAMMA-IFN MAB; MRL-LPR MOUSE; SYSTEMIC LUPUS ERYTHEMATOSUS; AUTOIMMUNE DISEASE;

D O I：

10.1016/0162-3109(92)90064-J

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effects of the in vivo treatment with a mAb (DB-1) that neutralizes mouse IFN-gamma on the development of the SLE-like syndrome in MRL/1pr-1pr (MRL-1pr) mice were studied. The results show that the i.p. administration of 2.6 mg/week of DB-1 from the 12th to the 20th week of age neither affected the survival nor the incidence and severity of lupus nephritis in MRL-1pr mice. This study argues against the pathogenic relevance of IFN-gamma in this experimental model of human SLE.

引用

页码：11 / 16

页数：6

共 20 条

[1] SPONTANEOUS MURINE LUPUS-LIKE SYNDROMES - CLINICAL AND IMMUNOPATHOLOGICAL MANIFESTATIONS IN SEVERAL STRAINS [J].