VIRAL EVASION OF CELLULAR DEFENSE-MECHANISMS - REGULATION OF THE PROTEIN-KINASE DAI BY RNA EFFECTORS

被引：69

作者：

MATHEWS, MB

机构：

[1] Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724

来源：

SEMINARS IN VIROLOGY | 1993年 / 4卷 / 04期

关键词：

PROTEIN KINASE DAI; EIF-2; DOUBLE-STRANDED RNA; VIRAL RNA; INTERFERON; ANTIVIRAL DEFENSE MECHANISMS;

D O I：

10.1006/smvy.1993.1021

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The protein kinase DAI (the double-stranded RNA activated inhibitor) plays a critical role in controlling translation in uninfected and infected cells. It is induced by interferon as part of the cellular antiviral defense mechanism. When activated, it leads to a blockade of polypeptide chain initiation, thereby interrupting viral propagation. Many viruses have developed means to neutralize the action of DAI: the sheer profusion of these countermeasures makes it clear that DAI is an important component of the host antiviral defense mechanism and a serious concern to the viruses. This chapter focusses on the mechanism of DAI activation and its inhibition by virus-encoded RNA antidotes. © 1993 Academic Press. All rights reserved.

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页码：247 / 257

页数：11

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