EXPRESSION OF CREATINE KINASE-M AND KINASE-B MESSENGER-RNAS IN TREADMILL TRAINED RAT SKELETAL-MUSCLE

被引：31

作者：

APPLE, FS ^{[1
]}

BILLADELLO, JJ ^{[1
]}

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT MED,ST LOUIS,MO 63110

来源：

LIFE SCIENCES | 1994年 / 55卷 / 08期

关键词：

CREATINE KINASE; B MESSENGER-RNA EXPRESSION; SKELETAL MUSCLE;

D O I：

10.1016/0024-3205(94)00484-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Gastroenemius muscle from treadmill trained rats was analyzed for creatine kinase (CK) isoenzyme activities by agarose electophoresis and M and B CK mRNA levels by Northern blot analysis. Total CK activity in exercise-trained (143 (SD 15) U/g) and control (154 (SD 16) U/g) muscles did not differ. CK-MB increased 220% in exercised-trained muscle compared to controls. CK-B subunit mRNA decreased 42% in exercised-trained muscle compared to control. Thus, gene expression of CK isoenzymes appears to be partially controlled at the level of transcription following exercise training.

引用

页码：585 / 592

页数：8

共 19 条

[1] MITOCHONDRIAL CREATINE-KINASE ACTIVITY ALTERATIONS IN SKELETAL-MUSCLE DURING LONG-DISTANCE RUNNING [J].