RAPID LOSS OF CD4+ T-CELLS IN HUMAN-PBL-SCID MICE BY NONCYTOPATHIC HIV ISOLATES

被引：166

作者：

MOSIER, DE

GULIZIA, RJ

MACISAAC, PD

TORBETT, BE

LEVY, JA

机构：

[1] MED BIOL INST, LA JOLLA, CA 92037 USA

[2] UNIV CALIF SAN FRANCISCO, SCH MED, CANC RES INST, DEPT MED, SAN FRANCISCO, CA 94143 USA

来源：

SCIENCE | 1993年 / 260卷 / 5108期

关键词：

D O I：

10.1126/science.8097595

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Human immunodeficiency virus (HIV) isolates differ in cell tropism, replication, pathogenicity, and syncytial induction in vitro. CD4+ T cells were enumerated in severe combined immunodeficient mice transplanted with human peripheral blood leukocytes (hu-PBL-SCID mice) and infected with HIV isolates with different in vitro cytopathicity. Two noncytopathic, macrophage-tropic strains, HIV-1SF162 and HIV-2UC1, induced extensive CD4+ T cell depletion, whereas HIV-1SF33, which is highly cytopathic for T cells in vitro, caused little CD4+ T cell depletion at equivalent virus burden. In vitro cytopathicity assays therefore do not predict CD4 depletion in the hu-PBL-SCID model.

引用

页码：689 / 692

页数：4

共 32 条

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