MOLECULAR-CLONING REVEALS THE EXISTENCE OF A 4TH-GAMMA-SUBUNIT OF THE VERTEBRATE BRAIN GABA(A) RECEPTOR

被引：55

作者：

HARVEY, RJ ^{[1
]}

KIM, HC ^{[1
]}

DARLISON, MG ^{[1
]}

机构：

[1] UNIV HAMBURG,KRANKENHAUS EPPENDORF,INST ZELLBIOCHEM & KLIN NEUROBIOL,MARTINISTR 52,D-20246 HAMBURG,GERMANY

来源：

FEBS LETTERS | 1993年 / 331卷 / 03期

关键词：

CDNA CLONING; CHICK BRAIN; GABA(A) RECEPTOR GAMMA-SUBUNIT; DEVELOPMENTAL GENE EXPRESSION; HYBRIDIZATION; IN-SITU; VISUAL PROCESSING;

D O I：

10.1016/0014-5793(93)80339-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have isolated a cDNA, from the chicken, that encodes a fourth type of gamma subunit of the vertebrate brain GABA(A) receptor. The mature polypeptide (which we name gamma4) displays 67%, 69% and 70% identity, respectively, to the rat gamma1, gamma2 and gamma3 subunits. In the developing chicken brain, the gamma4-subunit mRNA is first detected at embryonic day 13; the transcript level then increases progressively during embryogenesis. In situ hybridization reveals that the gamma4-subunit mRNA is abundant in several brain regions, including the ectostriatum, nucleus rotundus and hyperstriatum ventrale, which are involved in visual processing and learning.

引用

页码：211 / 216

页数：6

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