CHEMOTACTIC AND PROTEASE-INHIBITING ACTIVITIES OF ANTIBIOTIC PEPTIDE PRECURSORS

被引：66

作者：

VERBANAC, D ^{[1
]}

ZANETTI, M ^{[1
]}

ROMEO, D ^{[1
]}

机构：

[1] UNIV TRIESTE,DIPARTIMENTO BIOCHIM BIOFIS & CHIM MACROMOLEC,VIA VALERIO 32,I-34127 TRIESTE,ITALY

来源：

FEBS LETTERS | 1993年 / 317卷 / 03期

关键词：

BACTENECIN; PROBACTENECIN; MONOCYTE CHEMOTAXIS; CATHEPSIN-L INHIBITION;

D O I：

10.1016/0014-5793(93)81287-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have recently shown that two antimicrobial peptides (Bac5 and Bac7) and/or their immature forms (proBac5 and proBac7) can be released extracellularly from activated neutrophils. In the present study we have investigated the biological activities of the immature forms, which do not exhibit antimicrobial effects. We show that proBac7 is a monocyte-selective chemoattractant, potentially contributing to the recruitment of these cells to infection sites, whereas proBac5 efficiently inhibits the in vitro activity of cathepsin L, a cysteine proteinase thought to contribute to tissue injury in inflammation.

引用

页码：255 / 258

页数：4

共 24 条

[1]

Arnon R., 1970, METHOD ENZYMOL, V19, P226, DOI DOI 10.1016/0076-6879(70)19017-3

[2] PURIFICATION AND TISSUE DISTRIBUTION OF RAT CATHEPSIN-L [J].