ETHANOL INHIBITS GLUTAMATE-INDUCED CURRENTS IN HETEROMERIC NMDA RECEPTOR SUBTYPES

被引：92

作者：

KUNER, T ^{[1
]}

SCHOEPFER, R ^{[1
]}

KORPI, ER ^{[1
]}

机构：

[1] UNIV HEIDELBERG,CTR MOLEC BIOL,MOLEC NEUROENDOCRINOL LAB,HEIDELBERG,GERMANY

来源：

NEUROREPORT | 1993年 / 5卷 / 03期

关键词：

ETHANOL; ALCOHOL; N-METHYL-D-ASPARTATE (NMDA); GLUTAMATE;

D O I：

10.1097/00001756-199312000-00029

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

MAXIMAL L-glutamate/glycine-evoked currents were inhibited by ethanol in Xenopus laevis oocytes expressing recombinant heteromeric NMDA receptors consisting of NR1-NR2A, NR1-NR2B, and NR1-NR2C subunit combinations. Concentration-dependent inhibition was observed at ethanol concentrations of greater than or equal to 50 mM both in Ca2+-containing and Ca2+-deficient, Ba2+-containing Mg(2+)free media. The NR1-NR2C channels were slightly less sensitive to ethanol inhibition than the other heteromeric channels in Ca2+-deficient, Ba2+-containing medium. The inhibition was unaffected by the clamping-voltage and by a mutation [NR1-NR2A(N595Q)] that prevents the Mg2+-blockade of the channels, indicating that the mechanism of action of ethanol differs from that of Mg2+. The results are consistent with the hypothesis that the NMDA receptor subtypes can mediate many behavioural actions of ethanol.

引用

页码：297 / 300

页数：4

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