SYNTHESIS AND OPTICAL RESOLUTION OF HIGH-AFFINITY P-2-LIGANDS FOR HIV-1 PROTEASE INHIBITORS

被引：73

作者：

GHOSH, AK

CHEN, Y

机构：

[1] Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 04期

关键词：

D O I：

10.1016/0040-4039(94)02296-N

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Racemic bis-tetrahydrofuran ligand 6 was efficiently synthesized utilizing catalytic cobaloxime 10 mediated radical cyclization as the key step. Optical resolution of the racemic alcohol with immobilized-Amano lipase, afforded optically pure ligands.

引用

页码：505 / 508

页数：4

共 8 条

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