A SIMPLE DIFFUSION CELL TO MONITOR DRUG-RELEASE FROM SEMISOLID DOSAGE FORMS

被引：24

作者：

CHATTARAJ, SC ^{[1
]}

SWARBRICK, J ^{[1
]}

KANFER, I ^{[1
]}

机构：

[1] RHODES UNIV,SCH PHARMACEUT SCI,GRAHAMSTOWN 6140,SOUTH AFRICA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 120卷 / 01期

关键词：

DIFFUSION CELL; SEMISOLID DOSAGE FORM; DRUG RELEASE; IN VITRO RELEASE; ACYCLOVIR; DICLOFENAC; NYLON MEMBRANE; CELLULOSE ACETATE MEMBRANE;

D O I：

10.1016/0378-5173(94)00426-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A simple plexiglass cell was constructed and the in vitro release of acyclovir and diclofenac from semi-solid dosage forms was monitored using nylon and cellulose acetate membranes. The release of acyclovir was also monitored using Franz diffusion cells. Comparison of the data indicated that the rank order of release of acyclovir was the same using either the plexiglass or the Franz cells. However, data from the plexiglass cells indicated that better precision was obtained using this system as reflected by the much lower degree of variability between replicate experiments compared to the results obtained using the Franz cells. The results clearly indicate that the plexiglass cells provide a simple, precise and reliable system to monitor in vitro drug release from semi-solid dosage forms and do not suffer from the problem of having to remove air bubbles at the membrane/liquid interface which often occurs when using the Franz cells.

引用

页码：119 / 124

页数：6

共 21 条

[1]

Ayres, Laskar, Diffusion of benzocaine from ointment bases, J. Pharm. Sci., 63, pp. 1402-1406, (1974)

[2]

Behme, Kensler, Brooke, A new technique for determining in vitro release rates of drugs from creams, J. Pharm. Sci., 71, pp. 1303-1305, (1982)

[3]

Bottari, Dicolo, Nannipieri, Saettone, Serafini, Evaluation of a dynamic permeation technique for studying drug-macromolecule interactions, J. Pharm. Sci., 64, pp. 946-949, (1975)

[4]

Bottari, Dicolo, Nannipieri, Saettone, Serafini, Influence of drug concentration on in vitro release of salicylic acid from ointment bases, J. Pharm. Sci., 63, pp. 1779-1783, (1974)

[5]

Bottari, Dicolo, Nannipieri, Saettone, Serafini, Release of drug from ointment bases II: in vitro release of benzocaine from suspension - type aqueous gels, J. Pharm. Sci., 66, pp. 927-931, (1977)

[6]

Chowhan, Pritchard, Release of corticoids from oleaginous ointment bases containing drug in suspension, J. Pharm. Sci., 64, pp. 754-759, (1975)

[7]

Corbo, Schultz, Wong, Van Buskirk, Development and validation of in vitro release testing methods for semisolid formulations, Pharm. Tech., Sept., pp. 112-128, (1993)

[8]

Higuchi, Rate of release of medicaments from ointment base containing drug in suspension, J. Pharm. Sci., 50, pp. 874-875, (1961)

[9]

Kundu, Cameron, Meltzer, Quick, Development and validation of method for determination of in vitro release of retinoic acid from creams, Drug Dev. Ind. Pharm., 19, pp. 425-438, (1993)

[10]

Martin, Watts, Shroot, Jamoulle, A new diffusion cell - an automated method for measuring the pharmaceutical availability of topical dosage forms, Int. J. Pharm., 49, pp. 63-68, (1989)

← 1 2 3 →