PROBING THE D-1,4,5-IP3/D-1,3,4,5-IP4 FUNCTIONAL INTERFACE - SYNTHESIS AND PHARMACOLOGY OF NOVEL D-3-MODIFIED MYOINOSITOL TRISPHOSPHATE ANALOGS

被引：13

作者：

FAUQ, AH

KOZIKOWSKI, AP

OGNYANOV, VI

WILCOX, RA

NAHORSKI, SR

机构：

[1] MAYO FDN MED EDUC & RES, JACKSONVILLE, FL 32224 USA

[2] UNIV LEICESTER, DEPT CELL PHYSIOL & PHARMACOL, LEICESTER LE1 9HN, LEICS, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 11期

关键词：

D O I：

10.1039/c39940001301

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

To explore the biological significance of the D-3 position phosphorylation of the second messenger D-myo-inositol 1,4,5-trisphosphate (IP3) in cellular signalling, three novel D-3-substituted analogues of IP3 have been synthesized; their binding and Ca2+-release profiles at the IP3-receptor have been studied and shown to correlate with the steric requirement of the D-3 substituent.

引用

页码：1301 / 1302

页数：2

共 26 条

[1] RAPID FORMATION OF INOSITOL 1,3,4,5-TETRAKISPHOSPHATE FOLLOWING MUSCARINIC RECEPTOR STIMULATION OF RAT CEREBRAL CORTICAL SLICES
BATTY, IR
NAHORSKI, SR
IRVINE, RF
[J]. BIOCHEMICAL JOURNAL, 1985, 232 (01) : 211 - 215
[2] INOSITOL PHOSPHATES AND CELL SIGNALING
BERRIDGE, MJ
IRVINE, RF
[J]. NATURE, 1989, 341 (6239) : 197 - 205
[3] INOSITOL TRISPHOSPHATE AND CALCIUM SIGNALING
BERRIDGE, MJ
[J]. NATURE, 1993, 361 (6410) : 315 - 325
[4] PHOSPHOINOSITIDE 3-KINASE - A NEW EFFECTOR IN SIGNAL TRANSDUCTION
DOWNES, CP
CARTER, AN
[J]. CELLULAR SIGNALLING, 1991, 3 (06) : 501 - 513
[5] INOSITOL 1,3,4,5-TETRAKISPHOSPHATE STIMULATES CALCIUM RELEASE FROM BOVINE ADRENAL MICROSOMES BY A MECHANISM INDEPENDENT OF THE INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR
ELY, JA
HUNYADY, L
BAUKAL, AJ
CATT, KJ
[J]. BIOCHEMICAL JOURNAL, 1990, 268 (02) : 333 - 338
[6] INTERACTIONS BETWEEN INOSITOL TRIS-PHOSPHATES AND TETRAKIS-PHOSPHATES - EFFECTS ON INTRACELLULAR CA2+ MOBILIZATION IN SH-SY5Y CELLS
GAWLER, DJ
POTTER, BVL
GIGG, R
NAHORSKI, SR
[J]. BIOCHEMICAL JOURNAL, 1991, 276 : 163 - 167
[7] HIRATA M, 1993, J BIOL CHEM, V268, P19260
[8] HIRATA M, 1990, J BIOL CHEM, V265, P8404
[9] INOSITOL TETRAKISPHOSPHATE AS A 2ND MESSENGER - CONFUSIONS, CONTRADICTIONS AND A POTENTIAL RESOLUTION
IRVINE, RF
[J]. BIOESSAYS, 1991, 13 (08) : 419 - 427
[10] QUANTAL CA-2+ RELEASE AND THE CONTROL OF CA-2+ ENTRY BY INOSITOL PHOSPHATES - A POSSIBLE MECHANISM
IRVINE, RF
[J]. FEBS LETTERS, 1990, 263 (01): : 5 - 9

← 1 2 3 →