CODING SEQUENCE AND ALTERNATIVE SPLICING OF THE MOUSE ALPHA-1(XI) COLLAGEN GENE (COL11A1)

被引：15

作者：

YOSHIOKA, H ^{[1
]}

INOGUCHI, K ^{[1
]}

KHALEDUZZAMAN, M ^{[1
]}

NINOMIYA, Y ^{[1
]}

ANDRIKOPOULOS, K ^{[1
]}

RAMIREZ, F ^{[1
]}

机构：

[1] CUNY MT SINAI SCH MED,BROOKDALE CTR MOLEC BIOL,NEW YORK,NY 10029

来源：

GENOMICS | 1995年 / 28卷 / 02期

关键词：

D O I：

10.1006/geno.1995.1151

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Several overlapping cDNA clones corresponding to the entire coding sequence of the mouse alpha 1(XI) collagen gene (Col11a1) were isolated. The conceptual amino acid translation indicated a high degree of sequence identity (93%) with the human alpha 1(XI) chain. The cloning experiments also revealed alternative splicing of the sequence coding for 85 residues located within the acidic region of the amino-globular domain of alpha 1(XI). Analysis of RNA samples from different embryonic tissues suggested that alternative splicing might be confined to tissue destined to become bone. (C) 1995 Academic Press, Inc.

引用

页码：337 / 340

页数：4

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