EFFECT OF MOUSE GENOTYPE ON INTERFERON-PRODUCTION .3. EXPRESSION OF IF-1 BY PERITONEAL-MACROPHAGES INVITRO

Upon induction with Newcastle disease virus, peritoneal macrophages derived from C57BL/6 mice produced ten times as much interferon as macrophages derived from BALB/c mice. This suggested that the alleles of the If-1 locus are expressed in vitro by these cells. Further evidence for this was obtained by studying interferon production by peritoneal macrophages derived from seven recombinant inbred and one congenic line: in each case there was complete correlation between in vivo and in vitro phenotype: macrophages from If-1l mice were low producers in vitro, and macrophages from If-1h mice were high producers in vitro. © 1979 Springer-Verlag New York Inc.