PREPARATION OF H-3-LABELED APOMORPHINE, N-N-PROPYLNORAPOMORPHINE, AND O, O-DIPIVALOYLAPOMORPHINE

被引：11

作者：

SOINE, WH

SALGO, P

SMITH, RV

机构：

[1] Drug Dynamics Institute, College of Pharmacy, The University of Texas at Austin, Austin, Texas

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1979年 / 16卷 / 04期

关键词：

Apomorphine; N‐n‐propylnorapomorphine; O; O‐dipivaloylapomorphine; tritium;

D O I：

10.1002/jlcr.2580160412

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Apomorphine and N‐n‐propylnorapomorphine were tritiated using trifluoroacetic acid‐ tritiated water mixtures. This provides a route to the synthesis of tritiated O,O‐dipivaloylapomorphine. Deuterium exchange and NMR studies indicate that exchange only involves protons at the C‐8 and C‐9 positions. Copyright © 1979 John Wiley & Sons, Ltd.

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页码：597 / 601

页数：5

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