THE CONCENTRATION OF GLIAL FIBRILLARY ACIDIC PROTEIN INCREASES WITH AGE IN THE MOUSE AND RAT-BRAIN

被引：140

作者：

OCALLAGHAN, JP

MILLER, DB

机构：

[1] Neurotoxicology Division (MD-74B), Health Effects Research Laboratory U.S. Environmental Protection Agency, Research Triangle Park

来源：

NEUROBIOLOGY OF AGING | 1991年 / 12卷 / 02期

关键词：

GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP); AGING; SYNAPSIN-I; BETA-TUBULIN; NEUROFILAMENT-200; ASTROCYTE;

D O I：

10.1016/0197-4580(91)90057-Q

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The role of aging in the expression of the astrocyte protein, glial fibrillary acidic protein (GFAP), was examined. In both mice and rats the concentration of GFAP increased throughout the brain as a function of aging. The largest increase (2-fold) was observed in striatum for both species. The neuron-specific proteins, synapsin I and neurofilament-200 (M(r) 200 kilodaltons), were not altered by aging in any region of the mouse or rat brain. Brains of aged rats, but not mice, showed a decrease in beta-tubulin. The data suggest that astrocytic hypertrophy observed with aging involves an accumulation of glial filaments.

引用

页码：171 / 174

页数：4

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