DIODE-ARRAY DETECTION AND SIMULTANEOUS QUANTITATION OF THE COELUTING ATENOLOL-RELATED SYNTHETIC ROUTE IMPURITIES, PPA-DIOL

被引：7

作者：

OWINO, E

CLARK, BJ

FELL, AF

机构：

[1] Department of Pharmaceutical Chemistry, School of Pharmacy, University of Bradford, Bradford

来源：

JOURNAL OF CHROMATOGRAPHIC SCIENCE | 1991年 / 29卷 / 10期

关键词：

D O I：

10.1093/chromsci/29.10.450

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The diode array multichannel detector is used to acquire spectral information at specified intervals in the elution profile of atenolol and its related impurities for post-chromatographic data analysis. The applicability of a number of peak homogeneity testing methods, including spectral normalization, absorbance ratio, chromatographic derivatives, and spectral suppression (SS), are assessed for suitability in simultaneous determinations of the coeluting atenolol-related synthetic impurities, PPA-Diol. Spectral suppression displays a superior performance in comparison to all the other techniques in that both qualitative and quantitative information are acquired on the system.

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页码：450 / 456

页数：7

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