DIETING DECREASES PLASMA TRYPTOPHAN AND INCREASES THE PROLACTIN RESPONSE TO D-FENFLURAMINE IN WOMEN BUT NOT MEN

被引：49

作者：

WALSH, AES ^{[1
]}

OLDMAN, AD ^{[1
]}

FRANKLIN, M ^{[1
]}

FAIRBURN, CG ^{[1
]}

COWEN, PJ ^{[1
]}

机构：

[1] UNIV OXFORD, LITTLEMORE HOSP, DEPT PSYCHIAT, PSYCHOPHARMACOL RES UNIT, LITTLEMORE OX4 4XN, ENGLAND

来源：

JOURNAL OF AFFECTIVE DISORDERS | 1995年 / 33卷 / 02期

基金：

英国惠康基金;

关键词：

D-FENFLURAMINE; DIETING; TRYPTOPHAN; PROLACTIN; 5-HT;

D O I：

10.1016/0165-0327(94)00078-N

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied the effect of 3 weeks of moderate calorie restriction on 5-HT-mediated prolactin (PRL) release in healthy volunteers using the 5-HT-releasing agent d-fenfluramine. In women, dieting significantly lowered plasma total and free tryptophan (TRP) and increased the PRL response to d-fenfluramine. None of these measures were altered in men who dieted. These findings add to the data indicating that dieting alters brain 5-HT function in women, perhaps as a consequence of reducing the availability of plasma TRP.

引用

收藏

页码：89 / 97

页数：9

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