SAFETY AND IMMUNOGENICITY OF HEPATITIS-A VACCINE IN HEALTHY-CHILDREN

被引:49
作者
HORNG, YC
CHANG, MH
LEE, CY
SAFARY, A
ANDRE, FE
CHEN, DS
机构
[1] NATL TAIWAN UNIV HOSP,COLL MED,DEPT PEDIAT,Y CHUNG SHAN S RD,TAIPEI 100,TAIWAN
[2] NATL TAIWAN UNIV HOSP,COLL MED,DEPT INTERNAL MED,TAIPEI 100,TAIWAN
[3] SMITHKLINE BEECHAM BIOL SA,RIXENSART,BELGIUM
关键词
HEPATITIS-A VACCINE; IMMUNOGENICITY; REACTOGENICITY;
D O I
10.1097/00006454-199305000-00001
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The immunogenicity and reactogenicity of an inactivated hepatitis A (HA) vaccine in children were investigated. One hundred three healthy children who lacked antibody to HA virus (anti-HA virus), aged between 3 months and 6 years 8 months, were enrolled in this study. They received three doses of 360 enzyme-linked immunosorbent assay units of HA vaccine in a 0-, 1- and 6-month schedule. Blood tests for aminotransferase and anti-HA virus were performed 7 days before and 1, 6 and 7 months after the first dose. Anti-HA virus was tested by radioimmunoassay and also by enzyme immunoassay for titer determination. The seroconversion rates measured by enzyme immunoassay were 95.1% (98 of 103) at Month 1 and 100% at Months 6 and 7. Nine percent (28 of 309) of the injections were followed by local symptoms, usually mild soreness and swelling at the site of injection, and 12% (37 of 309) by minor general symptoms. We conclude that HA vaccine is highly immunogenic and safe in children. It may replace immunoglobulin as an effective method to prevent HA virus infection in children. We also suggest that the HA vaccine be administered to children in endemic areas.
引用
收藏
页码:359 / 362
页数:4
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