LIVER LIPID-PEROXIDATION AND GLUTATHIONE-RELATED DEFENSE ENZYME-SYSTEMS IN MICE TREATED WITH PARACETAMOL

被引:30
作者
OZDEMIRLER, G
AYKAC, G
UYSAL, M
OZ, H
机构
[1] Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, Istanbul, 34390, Capa
关键词
PARACETAMOL; LIPID PEROXIDATION; GLUTATHIONE S-TRANSFERASE (GST); GLUTATHIONE PEROXIDASE (GSH-PX); MOUSE LIVER;
D O I
10.1002/jat.2550140410
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Glutathione levels were found to be decreased while lipid peroxide levels were increased in total liver homogenates 6 h following paracetamol treatment (500 mg kg(-1) i.p.). Furthermore, it has been determined that cytosolic glutathione S-transferase (GST) activity was decreased and glutathione peroxidase (GSH-Px) activity remained unchanged. On the other hand, a decrease in liver microsomal lipid peroxide levels and an increase in GST and GSH-Px activity has been observed. We concluded that decreased lipid peroxide levels in microsomes could be a consequence of increased GSH-Px and GST enzyme activities. In this way, these glutathione-related defence enzyme systems may play an important role in protecting microsomes from lipid peroxidation.
引用
收藏
页码:297 / 299
页数:3
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