ANTI-ESTROGEN BASICITY ACTIVITY RELATIONSHIPS - A COMPARISON OF THE ESTROGEN-RECEPTOR BINDING AND ANTI-UTEROTROPHIC POTENCIES OF SEVERAL ANALOGS OF (Z)-1,2-DIPHENYL-1-[4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL]-1-BUTENE (TAMOXIFEN, NOLVADEX) HAVING ALTERED BASICITY

被引：121

作者：

ROBERTSON, DW

KATZENELLENBOGEN, JA

HAYES, JR

KATZENELLENBOGEN, BS

机构：

[1] UNIV ILLINOIS,SCH CHEM SCI,ROGER ADAMS LAB,URBANA,IL 61801

[2] UNIV ILLINOIS,DEPT PHYSIOL & BIOPHYS,URBANA,IL 61801

[3] UNIV ILLINOIS,COLL MED,SCH BASIC MED SCI,URBANA,IL 61801

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1982年 / 25卷 / 02期

关键词：

D O I：

10.1021/jm00344a015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：167 / 171

页数：5

共 26 条

[1]

ALBERT A, 1968, HETEROCYCLIC CHEM, P435

[2] UTERINE BIOASSAY OF TAMOXIFEN, TRIOXIFENE AND A NEW ESTROGEN ANTAGONIST (LY117018) IN RATS AND MICE [J].

BLACK, LJ ;

GOODE, RL .

LIFE SCIENCES, 1980, 26 (17) :1453-1458

[3] ESTROGENIC, ANTI-ESTROGENIC AND FERTILITY EFFECTS OF SOME TRIPHENYLETHANES AND TRIPHENYLETHYLENES RELATED TO ETHAMOXYTRIPHETOL (MER 25) [J].

CLARK, ER ;

JORDAN, VC .

BRITISH JOURNAL OF PHARMACOLOGY, 1976, 57 (04) :487-493

[4]

COREY EJ, 1968, TETRAHEDRON LETT, P5787

[5]

ECKERT RL, 1981, 63RD P ANN END SOC M, P125

[6]

EMMENS CW, 1969, J PHARMACOL EXP THER, V165, P52

[7] ANTI-ESTROGEN SPECIFIC, HIGH-AFFINITY SATURABLE BINDING-SITES IN RAT UTERINE CYTOSOL [J].

FAYE, JC ;

LASSERRE, B ;

BAYARD, F .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1980, 93 (04) :1225-1231

[8]

HARPER MJK, 1967, Patent No. 1064629

[9] BIOLOGICAL POTENCY AND UTERINE ESTROGEN-RECEPTOR INTERACTIONS OF THE METABOLITES OF THE ANTI-ESTROGEN - CI628 AND ANTIESTROGEN-U23,469 [J].

HAYES, JR ;

RORKE, EA ;

ROBERTSON, DW ;

KATZENELLENBOGEN, BS ;

KATZENELLENBOGEN, JA .

ENDOCRINOLOGY, 1981, 108 (01) :164-172

[10] TAMOXIFEN - REVIEW OF ITS PHARMACOLOGICAL PROPERTIES AND THERAPEUTIC USE IN TREATMENT OF BREAST-CANCER [J].

HEEL, RC ;

BROGDEN, RN ;

SPEIGHT, TM ;

AVERY, GS .

DRUGS, 1978, 16 (01) :1-24

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