Synthesis and Evaluation of the Anti-Oxidant Capacity of Curcumin Glucuronides, the Major Curcumin Metabolites

被引：48

作者：

Choudhury, Ambar K. ^{[1
]}

Raja, Suganya ^{[1
]}

Mahapatra, Sanjata ^{[1
]}

Nagabhushanam, Kalyanam ^{[2
]}

Majeed, Muhammed ^{[1
,2
]}

机构：

[1] Sami Labs Ltd, Bangalore 560058, Karnataka, India

[2] Sabinsa Corp, East Windsor, NJ 08520 USA

来源：

ANTIOXIDANTS | 2015年 / 4卷 / 04期

关键词：

curcumin monoglucuronide; Anti-oxidant; curcumin diglucuronide; DPPH; Synthesis; ORAC;

D O I：

10.3390/antiox4040750

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Curcumin metabolites namely curcumin monoglucuronide and curcumin diglucuronide were synthesized using an alternative synthetic approach. The anti-oxidant potential of these curcumin glucuronides was compared with that of curcumin using DPPH scavenging method and Oxygen Radical Absorbance Capacity (ORAC) assay. The results show that curcumin monoglucuronide exhibits 10 fold less anti-oxidant activity (DPPH method) and the anti-oxidant capacity of curcumin diglucuronide is highly attenuated compared to the anti-oxidant activity of curcumin.

引用

页码：750 / 767

页数：18

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