SCREENING FOR NEONATAL HYPO-THYROIDISM BY THYROXINE AND THYROTROPIN RADIOIMMUNOASSAYS USING DRIED BLOOD-SAMPLES ON FILTER-PAPER

被引：10

作者：

BECKERS, C

CORNETTE, C

FRANCOIS, B

BOUCKAERT, A

机构：

[1] Medical School, University of Louvain, Brussels

来源：

CLINICAL ENDOCRINOLOGY | 1979年 / 10卷 / 06期

关键词：

D O I：

10.1111/j.1365-2265.1979.tb02116.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A routine and automatized methodology for thyroxine (T4) and thyrotrophin (TSH) radioimmunoassay (RIA) using dried blood samples on filter paper is described. T4‐RIA was performed on one single dot (5 mm diameter equivalent to 4 μl of serum) while two dots were necessary for TSH‐RIA. Reference filter papers were introduced in each assay for quality control. In a preliminary study on 4,155 neonates, samples generally obtained between the 5th–7th day gave a mean ‘dot‐T4′ of 97.95 ± 36.04 nmol/l and a mean ‘dot‐TSH’ of 10.19 mU/l ±8.25, corresponding to 2.47 mU/l of serum. Within an 18‐month period (November 1976‐April 1978), a total of 16.522 neonates have been screened allowing detection of three cases of congenital hypothyroidism (incidence 1: 5507), two cases of congenitally low TBG and thirty‐three cases of transient hypothyroidism. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：567 / 573

页数：7

共 15 条

[1] CONGENITAL HYPO-THYROIDISM IN SWEDEN - INCIDENCE AND AGE AT DIAGNOSIS [J].