MULTIPLE SYMMETRIC LIPOMATOSIS (LAUNOIS-BENSAUDE SYNDROME) - ADIPOSE-TISSUE INSENSITIVITY TO CYCLIC-AMP

被引：39

作者：

DESAI, KS ^{[1
]}

ZINMAN, B ^{[1
]}

STEINER, G ^{[1
]}

机构：

[1] UNIV TORONTO, DEPT PHYSIOL, TORONTO M5S 1A8, ONTARIO, CANADA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1979年 / 49卷 / 02期

关键词：

D O I：

10.1210/jcem-49-2-307

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adipocytes prepared from lipomatous tissue of a patient with multiple symmetric lipomatosis have been incubated in the presence of norepinephrine, or insulin, or both. No lipolytic response to norepinephrine could be detected. However, the cellular content of cyclic AMP doubled in response to norepinephrine. Insulin reversed this. The data suggest that fat mobilization from the lipoma is impaired, and that this is due to resistance to the effect of cyclic AMP on hormone sensitive lipase. © 1979 by The Endocrine Society.

引用

页码：307 / 309

页数：3

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