CHRONIC RENAL-FAILURE IN CHILDREN TREATED WITH METHYL CCNU

被引：66

作者：

HARMON, WE

COHEN, HJ

SCHNEEBERGER, EE

GRUPE, WE

机构：

[1] CHILDRENS HOSP MED CTR,DEPT PATHOL,BOSTON,MA 02115

[2] CHILDRENS HOSP MED CTR,DIV HEMATOL & ONCOL,BOSTON,MA 02115

[3] SIDNEY FARBER CANC INST,BOSTON,MA 02115

[4] HARVARD UNIV,SCH MED,DEPT PEDIAT,BOSTON,MA 02115

[5] HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 1979年 / 300卷 / 21期

关键词：

D O I：

10.1056/NEJM197905243002106

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

METHYL CCNU (1- [2-chloroethyl] -3-[4-methyl cyclohexylj-1-nitrosourea) has been used to treat a variety of solid tumors1 2 3 for more than six years.4 It has been shown to be effective and to have an acceptable acute toxicity — mild gastrointestinal irritability and reversible bone-marrow suppression.1 The appearance of two patients previously treated with methyl CCNU in the end-stage renal-disease program at Children's Hospital Medical Center led us to review the effects of treatment with the drug at this hospital and at the Sidney Farber Cancer Institute. Our review disclosed a high incidence of renal failure in patients who had received methyl CCNU. © 1979, Massachusetts Medical Society. All rights reserved.

引用

页码：1200 / 1203

页数：4

共 16 条

[1]

CARTER S K, 1976, Cancer Treatment Reports, V60, P807

[2]

DENINE EP, 1977, CANCER TREAT REP, V61, P409

[3]

HEPTINSTALL RH, 1974, PATHOLOGY KIDNEY, P821

[4] RENAL SIZE IN NORMAL CHILDREN - A RADIOGRAPHIC STUDY DURING LIFE [J].

HODSON, CJ ;

KING, A ;

KARN, MN ;

DREWE, JA .

ARCHIVES OF DISEASE IN CHILDHOOD, 1962, 37 (196) :616-&

[5] NECROTIZING ARTERITIS IN ACUTE POSTSTREPTOCOCCAL GLOMERULONEPHRITIS - REPORT OF A RECOVERED CASE [J].

INGELFINGER, JR ;

MCCLUSKEY, RT ;

SCHNEEBERGER, EE ;

GRUPE, WE .

JOURNAL OF PEDIATRICS, 1977, 91 (02) :228-232

[6]

LUXTON RW, 1953, Q J MED, V22, P215

[7]

MAURICE P, 1978, CANCER, V41, P1658, DOI 10.1002/1097-0142(197805)41:5<1658::AID-CNCR2820410502>3.0.CO

[8]

2-I

[9]

OLIVERIO VT, 1973, CANCER CHEMOTH REP 3, V4, P13

[10]

OSBAND M, 1977, P AM ASSOC CANC RES, V18, P303

← 1 2 →