COMPUTER-BASED QUANTITATIVE MORPHOMETRIC ANALYSIS OF THE DYNAMIC CHARACTERISTICS OF INDOMETHACIN AND ETHANOL-INDUCED GASTRIC-LESIONS IN THE RAT

被引：6

作者：

GUGLIETTA, A

HERVADA, T

NARDI, RV

机构：

[1] From Glaxo Research Laboratories, Research Triangle Park

来源：

JOURNAL OF PHARMACOLOGICAL METHODS | 1990年 / 24卷 / 01期

关键词：

Computerized measurements; Ethanol; Gastric damage; Indomethacin; Morphometry; NSAID;

D O I：

10.1016/0160-5402(90)90051-L

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A computerized morphometric analysis was used to measure the gastric lesions in rats induced by oral administration of 2 mL of 100% EtOH or indomethacin 80 mg/kg. In both cases, the lesions were followed over a period of several days to determine their time course characteristics. Indomethacin lesions were present 1 hr after the administration of the drug and reached a peak after 6 hr. Ethanol lesions appeared as early as 1 min after administration and were fully expressed after 1 hr. Recovery of the gastric mucosa was observed after 2 and 6 days, respectively. The use of this computerized systems allows precise measurements of gastric lesions and facilitates the evaluation of the effect of drugs in the gastrointestinal tract. © 1990.

引用

页码：73 / 78

页数：6

共 17 条

[1]

BONTA IL, 1961, ARCH INT PHARMACOD T, V132, P147

[2]

BRAMBILLA A, 1987, PHARMACOL RES, V19, P147

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