CHEMICAL CHARACTERIZATION OF ACYLPOLYAMINE TOXINS FROM VENOM OF A TRAP-DOOR SPIDER AND 2 TARANTULAS

被引：43

作者：

SKINNER, WS

DENNIS, PA

LUI, A

CARNEY, RL

QUISTAD, GB

机构：

[1] Sandoz Crop Protection Corporation, Research Division, Palo Alto, CA 94304

来源：

TOXICON | 1990年 / 28卷 / 05期

关键词：

D O I：

10.1016/0041-0101(90)90298-L

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Two acylpolyamines are identified from venom of the trap-door spider, Hebestatis theveniti. These toxins (paralytic to lepidopteran insect larvae) are amides containing 3-(3-indolyl)lactic acid joined to spermine or 1,13-diamino-4,10-diazatridecane (Het389 and Het403, respectively). Het389 is also abundant in venom from a tarantula from Mozambique (Harpactirella sp.). Two additional acylpolyamines (Apc600 and Apc728) are partially characterized from venom of another tarantula, Aphonopelma chalcodes. © 1990.

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页码：541 / 546

页数：6

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