PARKINSONISM IN MONKEYS PRODUCED BY CHRONIC ADMINISTRATION OF AN ENDOGENOUS SUBSTANCE OF THE BRAIN, TETRAHYDROISOQUINOLINE - THE BEHAVIORAL AND BIOCHEMICAL-CHANGES

被引：79

作者：

YOSHIDA, M

NIWA, T

NAGATSU, T

机构：

[1] NAGOYA UNIV,SCH MED,DEPT BIOCHEM,65 TSURUMAI CHO,SHOWA KU,NAGOYA,AICHI 466,JAPAN

[2] JICHI MED SCH,DEPT NEUROL,MINAMI KAWACHI,TOCHIGI 32904,JAPAN

[3] NAGOYA UNIV BRANCH HOSP,DEPT INTERNAL MED,NAGOYA,JAPAN

来源：

NEUROSCIENCE LETTERS | 1990年 / 119卷 / 01期

关键词：

Biopterin; Dopamine; Parkinsonism; Squirrel monkeys; Striatum; Substantia nigra; Tetrahydroisoquinoline; Tyrosine hydroxylase;

D O I：

10.1016/0304-3940(90)90768-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have examined the effect of chronic administration of a probable endogenous dopaminergic neurotoxin, tetrahydroisoquinoline (TIQ, 20 mg/kg per day, s.c. for up to 104 days), on squirrel monkeys. Chronically administered TIQ produced motor symptoms similar to parkinsonism in squirrel monkeys even after 7 days' discontinuation of TIQ and the symptomes were alleviated remarkably by levodopa treatment. Biochemical analysis of the brains of TIQ-treated monkeys revealed significant decrease in dopamine (DA) and total biopterin (BP) concentrations, and tyrosine hydroxylase (TH) activity in the substantia nigra, and these biochemical changes were not reversed by 7 days following the termination of chronic administration of TIQ. TIQ was identified in the brain (caudate-putamen) of saline-injected control monkeys by gas chromatography-mass spectrometry. The endogenous levels of TIQ in the caudate-putamen was about 0.15 μg/g, and increased up to 3-4 μg/g, 1 day as well as 7 days following termination of TIQ administration. © 1990.

引用

页码：109 / 113

页数：5

共 22 条

[1] A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].