EFFECT OF BETA-ENDORPHIN ON CALCIUM-UPTAKE IN THE BRAIN

被引：63

作者：

GUERREROMUNOZ, F ^{[1
]}

DELOURDESGUERRERO, M ^{[1
]}

WAY, EL ^{[1
]}

LI, CH ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,HORMONE RES LAB,SAN FRANCISCO,CA 94143

来源：

SCIENCE | 1979年 / 206卷 / 4414期

关键词：

D O I：

10.1126/science.39340

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The uptake of 45Ca2+ by nerve-ending fractions from brains of mice was inhibited in vitro by 10-9M concentrations of β-endorphin and in mice injected intraventricularly with 7 picomoles of β-endorphin. That the effect was a specific opiate agonist response of β-endorphin was demonstrated by use of the opiate antagonist, naloxone, which reversed the action. A role for β-endorphin in the regulation of calcium flux and neurotransmitter release should be considered. Copyright © 1979 AAAS.

引用

页码：89 / 91

页数：3

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