REGIONAL DISTRIBUTION OF EXTRACELLULAR 5-HYDROXYTRYPTAMINE AND 5-HYDROXYINDOLEACETIC ACID IN THE BRAIN OF FREELY MOVING RATS

被引：68

作者：

ADELL, A ^{[1
]}

CARCELLER, A ^{[1
]}

ARTIGAS, F ^{[1
]}

机构：

[1] CSIC,DEPT NEUROCHEM,JORDI GIRONA 18-26,E-08034 BARCELONA,SPAIN

来源：

JOURNAL OF NEUROCHEMISTRY | 1991年 / 56卷 / 02期

关键词：

5-HYDROXYTRYPTAMINE; INTRACEREBRAL MICRODIALYSIS; REGIONAL DISTRIBUTION; RAPHE;

D O I：

10.1111/j.1471-4159.1991.tb08208.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The extracellular concentrations of 5-hydroxytryptamine (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) have been determined in six brain areas of awake rats (frontal cortex, striatum, hypothalamus, hippocampus, inferior colliculus, and raphe nuclei) using intracerebral microdialysis. The extracellular levels of 5-HT showed no significant differences among the brain regions studied. The tissue levels of 5-HT and 5-HIAA as well as the extracellular concentration of 5-HIAA were significantly higher in raphe nuclei. The regional distribution of tissue and extracellular 5-HIAA were very similar, suggesting that extracellular 5-HIAA depends mainly on the output from the intracellular compartment. On the other hand, extracellular 5-HT and tissue 5-HT showed a different distribution pattern. The tissue/extracellular ratio for 5-HT ranged from 739 in frontal cortex to 2,882 in raphe, whereas it only amounted to 1.8-3.6 for 5-HIAA. The relationship between the present results and the density of 5-HT uptake sites in these areas is discussed.

引用

页码：709 / 712

页数：4

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