ISCOMS - A NOVEL STRATEGY FOR MUCOSAL IMMUNIZATION

被引：73

作者：

MOWAT, AM

DONACHIE, AM

机构：

[1] Dept o f Immunology, University of Glasgow, Western Infirmary, Glasgow

来源：

IMMUNOLOGY TODAY | 1991年 / 12卷 / 11期

关键词：

D O I：

10.1016/0167-5699(91)90133-E

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Orally-active vaccines containing purified or recombinant antigens are highly desirable, particularly in immunization against diseases of mucosal surfaces, but their development to date has been limited and fitful, hampered by a range of difficulties. Here, Allan Mowat and Anne Donachie suggest that lipophilic immune-stimulating complexes (ISCOMS) may provide an oral immunization vector for the induction of a wide range of immune responses to protein antigens.

引用

页码：383 / 385

页数：3

共 16 条

[1] BLOOM BR, 1989, NATURE, V342, P15
[2] CHALLACOMBE SJ, 1987, FOOD ALLERGY INTOLER, P269
[3] ADJUVANT EFFECTS OF ORALLY-ADMINISTERED SAPONINS ON HUMORAL AND CELLULAR IMMUNE-RESPONSES IN MICE
CHAVALI, SR
CAMPBELL, JB
[J]. IMMUNOBIOLOGY, 1987, 174 (03) : 347 - 359
[4] CONTROLLED VACCINE RELEASE IN THE GUT-ASSOCIATED LYMPHOID-TISSUES .1. ORALLY-ADMINISTERED BIODEGRADABLE MICROSPHERES TARGET THE PEYERS PATCHES
ELDRIDGE, JH
HAMMOND, CJ
MEULBROEK, JA
STAAS, JK
GILLEY, RM
TICE, TR
[J]. JOURNAL OF CONTROLLED RELEASE, 1990, 11 (1-3) : 205 - 214
[5] CELLULAR IMMUNE-RESPONSES IN THE MURINE LUNG TO LOCAL IMMUNIZATION WITH INFLUENZA-A VIRUS GLYCOPROTEINS IN MICELLES AND IMMUNOSTIMULATORY COMPLEXES (ISCOMS)
JONES, PD
HLA, RT
MOREIN, B
LOVGREN, K
ADA, GL
[J]. SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1988, 27 (06) : 645 - 652
[6] KENSIL CR, 1991, J IMMUNOL, V146, P431
[7] THE SERUM ANTIBODY-RESPONSE DISTRIBUTED IN SUBCLASSES AND ISOTYPES AFTER INTRANASAL AND SUBCUTANEOUS IMMUNIZATION WITH INFLUENZA-VIRUS IMMUNOSTIMULATING COMPLEXES
LOVGREN, K
[J]. SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1988, 27 (02) : 241 - 245
[8] LYCKE N, 1986, IMMUNOLOGY, V59, P301
[9] THE ISCOM - AN IMMUNOSTIMULATING COMPLEX
MOREIN, B
LOVGREN, K
HOGLUND, S
SUNDQUIST, B
[J]. IMMUNOLOGY TODAY, 1987, 8 (11): : 333 - 338
[10] INCREASED IMMUNOGENICITY OF A NONAMPHIPATHIC PROTEIN (BSA) AFTER INCLUSION INTO ISCOMS
MOREIN, B
EKSTROM, J
LOVGREN, K
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1990, 128 (02) : 177 - 181

← 1 2 →