TETRAHYDROBIOPTERIN INDUCES VASODILATATION VIA ENHANCEMENT OF CGMP LEVEL

被引：26

作者：

VANAMSTERDAM, JGC

WEMER, J

机构：

[1] National Institute of Public Health and Environmental Protection, 3720 BA Bilthoven

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 215卷 / 2-3期

关键词：

TETRAHYDROBIOPTERIN; VASODILATATION; NITRIC OXIDE SYNTHASE;

D O I：

10.1016/0014-2999(92)90056-A

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Studies with cell homogenates and cultures had indicated earlier that nitric oxide (NO) synthase is dependent on tetrahydrobiopterin, which apparently functions as a cofactor for the enzyme. The present results showed a vasodilator response to tetrahydrobiopterin in precontracted aorta, which is attained via an increase of the intracellular cyclic GMP level. Furthermore, L-N(g)-nitro-arginine-methyl ester inhibits the tetrahydrobiopterin-induced vasodilation, showing the involvement of NO synthase.

引用

页码：349 / 350

页数：2

共 5 条

[1] HUBER C, 1983, J IMMUNOL, V130, P1047
[2] KWON NS, 1989, J BIOL CHEM, V264, P20496
[3] PURIFICATION OF A CA-2+/CALMODULIN-DEPENDENT NITRIC-OXIDE SYNTHASE FROM PORCINE CEREBELLUM - COFACTOR-ROLE OF TETRAHYDROBIOPTERIN
MAYER, B
JOHN, M
BOHME, E
[J]. FEBS LETTERS, 1990, 277 (1-2) : 215 - 219
[4] BIOSYNTHESIS AND METABOLISM OF TETRAHYDROBIOPTERIN AND MOLYBDOPTERIN
NICHOL, CA
SMITH, GK
DUCH, DS
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1985, 54 : 729 - 764
[5] TAYEH MA, 1989, J BIOL CHEM, V264, P19654

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