SIMULTANEOUS DETERMINATION OF TENIDAP AND ITS STABLE ISOTOPE ANALOG IN SERUM BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ATMOSPHERIC-PRESSURE CHEMICAL IONIZATION TANDEM MASS-SPECTROMETRY

被引：33

作者：

AVERY, MJ ^{[1
]}

MITCHELL, DY ^{[1
]}

FALKNER, FC ^{[1
]}

FOUDA, HG ^{[1
]}

机构：

[1] PFIZER INC,DIV CENT RES,EASTERN POINT RD,GROTON,CT 06340

来源：

BIOLOGICAL MASS SPECTROMETRY | 1992年 / 21卷 / 07期

关键词：

D O I：

10.1002/bms.1200210706

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A specific high-performance liquid chromatographic/atmospheric pressure chemical ionization tandem mass spectrometric assay for the quantitative determination of tenidap and its D, analog in human serum is described. The assay exhibited a linear dynamic range of 0.1-25-mu-g ml-1. Its precision for the two analytes over the range was 17% or better. The assay validity and its utility to investigate changes in tenidap bioequivalence and pharmacokinetics are presented.

引用

页码：353 / 357

页数：5

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