SERIAL P-31 MR SPECTROSCOPY AFTER FRUCTOSE INFUSION IN PATIENTS WITH CHRONIC HEPATITIS

被引：6

作者：

SAKUMA, H

ITABASHI, K

TAKEDA, K

HIRANO, T

KINOSADA, Y

NAKAGAWA, T

YAMADA, M

NAKANO, T

机构：

[1] Department of Radiology, Mie University school of Medicine, Tsu, Mie, 514

[2] First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, 514

[3] Department of Radilogy, Imakiire, General Hospital, Ka-Goshima

来源：

JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING | 1991年 / 1卷 / 06期

关键词：

HEPATITIS; LIVER; FUNCTION; MR STUDIES; MAGNETIC RESONANCE (MR); SPECTROSCOPY; METABOLISM; PHOSPHORUS STUDIES;

D O I：

10.1002/jmri.1880010615

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Serial changes in phosphorus metabolites after intravenous administration of fructose were compared between five healthy volunteers and five patients with chronic hepatitis by means of phosphorus-31 magnetic resonance (MR) spectroscopy. P-31 spectra were obtained every 5 minutes after intravenous drip infusion of 20% fructose at a dose of 0.5 g/kg of body weight. In the healthy volunteers, phosphomonoesters (PME) increased to 338% +/- 76% of the preadministration value at 15-20 minutes. Inorganic phosphate (Pi) was depleted in the first 15 minutes, then rebounded to 260% +/- 67% of the initial value. beta-adenosine triphosphate decreased to less than 50% of its initial value and then gradually recovered. In patients with chronic hepatitis, the increase of PME at 15-20 minutes (151% +/- 49% of the preadministration value) was significantly less than that in healthy volunteers (P < .05). In addition, the rebound of Pi at 35-40 minutes (126% +/- 42%) was significantly less than that in healthy volunteers (P < .05). In conclusion, P-31 MR spectroscopy with fructose administration is valuable in the functional evaluation of diffuse liver diseases.

引用

页码：701 / 704

页数：4

共 9 条

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