CONTROLLED TRIAL OF METHOTREXATE VERSUS 10-DEAZAAMINOPTERIN IN THE TREATMENT OF RHEUMATOID-ARTHRITIS

被引：6

作者：

ALARCON, GS

CASTANEDA, O

NAIR, MG

FERRANDIZ, M

KOOPMAN, WJ

KRUMDIECK, CL

机构：

[1] UNIV ALABAMA,DEPT MED,DIV CLIN IMMUNOL & RHEUMATOL,BIRMINGHAM,AL 35233

[2] UNIV HOSP LIMA,CAYETANO HEREDIA,DEPT MED,RHEUMATOL UNIT,LIMA,PERU

[3] UNIV ALABAMA,DEPT NUTR SCI,BIRMINGHAM,AL 35233

[4] VET ADM MED CTR,BIRMINGHAM,AL 35233

[5] UNIV SO ALABAMA,DEPT BIOCHEM,MOBILE,AL 36688

来源：

ANNALS OF THE RHEUMATIC DISEASES | 1992年 / 51卷 / 05期

关键词：

D O I：

10.1136/ard.51.5.600

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

A 15 week double blind controlled trial of methotrexate and 10-deazaaminopterin for the treatment of rheumatoid arthritis (RA) was performed in 26 patients. Significant improvement in all measured clinical parameters was observed in the two patient groups. The drugs were well tolerated; only one patient (10-deazaaminopterin) withdrew from the study because of side effects. It is concluded that, in the context of this relatively short clinical trial, 10-deazaaminopterin is at least as beneficial as methotrexate in the treatment of RA.

引用

页码：600 / 603

页数：4

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