LACK OF ASSOCIATION OF HUMAN POLYOMAVIRUSES WITH HUMAN BRAIN-TUMORS

被引：47

作者：

ARTHUR, RR

GROSSMAN, SA

RONNETT, BM

BIGNER, SH

VOGELSTEIN, B

SHAH, KV

机构：

[1] JOHNS HOPKINS UNIV, SCH HYG & PUBL HLTH, DEPT IMMUNOL & INFECT DIS, BALTIMORE, MD 21205 USA

[2] JOHNS HOPKINS UNIV, SCH MED, DEPT PATHOL, BALTIMORE, MD 21205 USA

[3] JOHNS HOPKINS UNIV, CTR ONCOL, BALTIMORE, MD 21205 USA

来源：

JOURNAL OF NEURO-ONCOLOGY | 1994年 / 20卷 / 01期

关键词：

POLYOMAVIRUSES; BKV; JCV; BRAIN TUMORS; POLYMERASE CHAIN REACTION; PCR;

D O I：

10.1007/BF01057961

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Brain tumors, primarily glioblastoma multiforme, were examined for the presence of BKV DNA. DNAs extracted from 33 fresh-frozen tumors and from an additional 47 paraffin-embedded tumor tissues were tested for BKV sequences using two different primer pairs. One primer pair amplified highly conserved sequences in the early region coding for BKV and JCV T antigens. The other primer pair amplified the regulatory region of BKV-IR, a variant previously associated with human brain tumors. None of the tumors were positive for BKV or JCV DNA.

引用

页码：55 / 58

页数：4

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