A REAPPRAISAL OF THE MEASUREMENT OF GLOMERULAR-FILTRATION RATE IN PRETERM INFANTS

被引:13
作者
WILKINS, BH
机构
[1] Department of Child Health, Bristol University, Bristol
[2] Neonatal Intensive Care Unit, Southmead Hospital, Bristol
关键词
GLOMERULAR FILTRATION RATE; PRETERM INFANT; NEWBORN; INULIN; POLYFRUCTOSAN-S; CREATININE; CLEARANCE;
D O I
10.1007/BF00869724
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Thirty-seven single-injection polyfructosan-S (PF-S, Inutest(R)) and 98 continuous-infusion PF-S/creatinine clearance studies were performed in 39 sick very low birth weight infants. The single-injection clearance method for measuring glomerular filtration rate has been shown to be a reliable technique if sampling is continued for 8 h or more and the PF-S (Inutest(R)) assay is sensitive, accurate and precise. The continuous-infusion clearance method is also valid if the infusion is continued for more than 24 h and preceded by a loading dose in the form of a double-rate infusion for 8 h. Creatinine clearance is usually less than PF-S clearance, the mean ratio being 0.91, suggesting that there is some creatinine reabsorption in the renal tubule in sick very low birth weight infants.
引用
收藏
页码:323 / 327
页数:5
相关论文
共 28 条
[1]  
Coulthard M.G., Ruddock V., Validation of inulin as a marker for glomerular filtration in pre-term babies, Kidney Int, 23, pp. 407-409, (1983)
[2]  
Wilkins B.H., The glomerular filterability of polyfructosan-S in immature infants, Pediatr Nephrol, 6, pp. 323-327, (1992)
[3]  
Coulthard M.G., Comparison of methods of measuring renal function in preterm babies using inulin, J Pediatr, 102, pp. 923-930, (1983)
[4]  
Guignard J-P, Assessment of renal function without urine collection, Arch Dis Child, 52, (1977)
[5]  
Rose G.A., Measurement of glomerular filtration rate by inulin clearance without urine collection, BMJ, 2, pp. 91-93, (1969)
[6]  
Cole B.R., Giangiacomo J., Ingelfinger J.R., Robson A.M., Measurement of renal function without urine collection. A critical evaluation of the constant infusion technic for determination of inulin and para-aminohippurate, N Engl J Med, 287, pp. 1109-1114, (1972)
[7]  
Fawer C-L, Torrado A., Guignard J-P, Single injection clearance in the neonate, Biol Neonate, 35, pp. 321-324, (1979)
[8]  
Coulthard M.G., Maturation of glomerular filtration in pre-term and mature babies, Early Hum Dev, 11, pp. 281-292, (1985)
[9]  
Keen D.V., Pearse R.G., Weight, length and head circumference curves for boys and girls between 20 and 42 weeks gestation, Arch Dis Child, 63, pp. 1170-1172, (1988)
[10]  
Sapirstein L.A., Widt D.C., Mandel M.J., Hanusek G., Volumes of distribution and clearances of intravenously injected creatinine in the dog, Am J Physiol, 181, pp. 330-336, (1955)