A PLACENTAL CLOCK CONTROLLING THE LENGTH OF HUMAN-PREGNANCY

被引:703
作者
MCLEAN, M
BISITS, A
DAVIES, J
WOODS, R
LOWRY, P
SMITH, R
机构
[1] JOHN HUNTER HOSP,MATERNAL HLTH RES CTR,NEWCASTLE,NSW 2310,AUSTRALIA
[2] UNIV READING,SCH ANIM & MICROBIAL SCI,READING RG6 2AJ,BERKS,ENGLAND
关键词
D O I
10.1038/nm0595-460
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We report the existence of a 'placental clock', which is active from an early stage in human pregnancy and determines the length of gestation and the timing of parturition and delivery. Using a prospective, longitudinal cohort study of 485 pregnant women we have demonstrated that placental secretion of corticotropin-releasing hormone (CRH) is a marker of this process and that measurement of the maternal plasma CRH concentration as early as 16-20 weeks of gestation identifies groups of women who ale destined to experience normal term, preterm or post-term delivery. Further, we report that the exponential rise in maternal plasma CRH concentrations with advancing pregnancy is associated with a concomitant fall in concentrations of the specific CRH binding protein in late pregnancy, leading to a rapid increase in circulating levels of bioavailable CRH at a time that coincides with the onset of parturition, suggesting that CRH may ad directly as a trigger for parturition in humans.
引用
收藏
页码:460 / 463
页数:4
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