BIODEGRADATION OF PLA/GA POLYMERS - INCREASING COMPLEXITY

被引：335

作者：

VERT, M

MAUDUIT, J

LI, SM

机构：

[1] Centre de Recherche sur les Biopolymères Artificiels, LIRA CNRS 1465 Université Montpellier 1, Faculté de Pharmacie, 34060 Montpellier Cedex

来源：

BIOMATERIALS | 1994年 / 15卷 / 15期

关键词：

BIODEGRADATION; POLY(LACTIC ACID); COPOLYMERS;

D O I：

10.1016/0142-9612(94)90271-2

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The degradation of aliphatic polyesters derived from lactic and glycolic acids (PLA/GA) depends on many factors. It has been found recently that the interior of large size devices degrades faster than the outer zone. A qualitative model has been proposed to account for this heterogeneous degradation. It is based on diffusion-reaction phenomena combined with the well-known autocatalytic effect of carboxyl ic chain ends. This contribution recalls the present understanding of the hydrolytic degradation of PLA/GA polymers and emphasizes its complexity on the basis of the influence of secondary factors such as the presence of a basic load, namely, gentamycin, in poly(lactic acid) matrices, and the presence of long stereoregular sequences in poly(DL-lactic acid) macromolecules.

引用

页码：1209 / 1213

页数：5

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