CLINICAL-TRIAL OF TRIMEBUTINE (MEBUTIN) IN SPASTIC COLON

被引：85

作者：

MOSHAL, MG ^{[1
]}

HERRON, M ^{[1
]}

机构：

[1] UNIV NATAL,KING EDWARD VIII HOSP,DEPT MED,GASTRO INTESTINAL UNIT,DURBAN,SOUTH AFRICA

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 1979年 / 7卷 / 03期

关键词：

D O I：

10.1177/030006057900700311

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Twenty adult Indian patients suffering from the spastic form of irritable colon, i.e. abdominal pain and constipation, were given trimebutine (Mebutin), 2-phenyl, 2-dimethylamino-n-butyl 3, 4, 5-trimethoxybenzoate. Patients were given treatment with 200 mg trimebutine three times daily, or placebo for 4 weeks, and then crossed over. In addition, stool transit times were assessed by the single stool transit time (SST) method of Cummings. Results showed a statistical improvement in abdominal pain and constipation with both trimebutine and placebo after 4 weeks, but only with trimebutine after 8 weeks. Single stool transit time was significantly reduced after trimebutine. © 1979, SAGE Publications. All rights reserved.

引用

页码：231 / 234

页数：4