EATING BEHAVIOR AND ADHERENCE TO DIETARY PRESCRIPTIONS IN OBESE ADULT SUBJECTS TREATED WITH 5-HYDROXYTRYPTOPHAN

被引:54
作者
CANGIANO, C
CECI, F
CASCINO, A
DELBEN, M
LAVIANO, A
MUSCARITOLI, M
ANTONUCCI, F
ROSSIFANELLI, F
机构
[1] UNIV ROME LA SAPIENZA, DEPT INTERNAL MED 3, CLIN NUTR LAB, VIALE UNIV 37, I-00185 ROME, ITALY
[2] UNIV ROME LA SAPIENZA, DEPT HUMAN BIOPATHOL, I-00185 ROME, ITALY
[3] UNIV ROME LA SAPIENZA, IST TERAPIA MED SISTEMAT, SERV DIETET, I-00185 ROME, ITALY
关键词
EATING BEHAVIOR; ANOREXIA; 5-HYDROXYTRYPTOPHAN; SEROTONIN; OBESITY; ADHERENCE TO DIET; APPETITE FOR CARBOHYDRATES; WEIGHT LOSS;
D O I
10.1093/ajcn/56.5.863
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Previous observations have shown that oral administration of 5-hydroxytryptophan (5-HTP) without dietary prescriptions causes anorexia, decreased food intake, and weight loss in obese subjects. To confirm these data over a longer period of observation and to verify whether adherence to dietary restriction could be improved by 5-HTP, 20 obese patients were randomly assigned to receive either 5-HTP (900 mg/d) or a placebo. The study was double-blinded and was for two consecutive 6-wk periods. No diet was prescribed during the first period, a 5040-kJ/d diet was recommended for the second. Significant weight loss was observed in 5-HTP-treated patients during both periods. A reduction in carbohydrate intake and a consistent presence of early satiety were also found. These findings together with the good tolerance observed suggest that 5-HTP may be safely used to treat obesity.
引用
收藏
页码:863 / 867
页数:5
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